Part:BBa_K314201:Experience

Evidence that Tsi2 works as expected

This evidence can be found on [http://2010.igem.org/Team:Washington/Gram_Negative/Test this page] from the 2010 UW iGEM Wiki, under the heading "Evidence that Tse2 and Tsi2 are Function As Expected"

Applications of BBa_K314201

Tsi2 is necessary for the generation of Gram-negative bacteria that have been directed to target other Gram-negative bacteria for killing by Tse2 in response to a user-defined signal. Tsi2 is necessary because it protects host cells from death caused by the Tse2 toxic protein.

If the antitoxin Tsi2 is combined with a functioning Type 6 Secretion System and the toxin Tse2 it results in a killing system that can be targeted to Gram-negative bacteria. This could be used in a probiotic application. This was the goal behind the Gram-negative portion of the [http://2010.igem.org/Team:Washington 2010 UW iGEM project].

User Reviews

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